Research Symposium Program - Individual Details
5th annual Undergraduate Research Symposium, April 17, 2025
Lin Alkader
BIO
My name is Lin Alkader and I'm a freshman studying Biological Science. My goal is to finish my Bachelor’s degree and graduate FSU to finish my path in medicine.
The melting point phase diagram of a cocrystal between L-Proline and Naproxen
Authors: Lin Alkader, Dr. Paul W. BauresStudent Major: Biological Sciences
Mentor: Dr. Paul W. Baures
Mentor's Department: Chemistry Mentor's College: Florida State University-Panama City Co-Presenters:
Abstract
This experiment focuses on a selected cocrystal system model to understand cocrystal formation using Naproxen and L-Proline. Naproxen is known as a slow-absorbing pain reliever and nonsteroidal anti-inflammatory drug (NSAID) in the profen family, and L-proline is a very successful amino acid cocrystal stabilizing coformer. Researchers interested in zwitterionic cocrystals can use them to make cocrystals due to their conventional chemical properties in active pharmaceutical ingredients (API). We will be using a melting point phase diagram and Differential Scanning Calorimetry (DSC) to collect data and other measurements and analyze their temperatures. The melting point phase diagram of the solid cocrystals will be determined by mixing different ratios of L-Proline to Naproxen to note and analyze their changing melting points. To conclude this experiment, we will establish a melting point phase diagram of organic cocrystal formation using pharmaceutical drugs like L-proline and Naproxen.
Keywords: co-crystal, melting point, and phase diagram